Correlation between HDAC6 expression and clinical features of renal cell carcinoma

Background: Currently, the expression of HDAC6 in renal cell carcinoma has not yet been reported. Only little is known about the relationship between HDAC6 and clinical features of renal cell carcinoma as well. This study is aimed to verify the correlation between the expression of HDAC6 and clinical features of the patients with renal cell carcinoma. Methods: 90 patients with renal cell carcinoma were engaged in the study. The renal cell carcinoma tissues and the neighbored normal tissues were collected. By immunohistochemistry staining and tissue microarray, the expression of HDAC6 in both tissues was assessed. Results: HDAC6 in renal cell carcinoma tissue was showed significant lower expression than that in the neighbored normal tissues (P < 0.05). The Spearman’s correlation assay proved that the expression of HDAC6 in renal cell carcinoma tissue was significantly positive related to T stage and AJCC clinical stages in renal cell tissues (r > 0, P < 0.05), while that in neighbored normal tissue was significantly negative related to pathological stages, T stage and AJCC clinical stages (r < 0, P < 0.05). Kaplan-Meier assay and log-rank test proved that high expression of HDAC6 in renal cell carcinoma tissue induced lower survival rate (P < 0.05), but that in neighbored normal tissue induced higher survival rate (P = 0.052). Conclusion: HDAC6 might perform different functions in renal cell carcinoma tissue and neighbored normal tissue; it might promote tumor angiogenesis in renal cell carcinoma tissue but suppress the tumorigenesis in the normal kidney tissue.